Various stressors, including DNA damage, Oxidative stress, Oncogene activation, Irradiation, and Certain cytokines, can cause senescent cells.
Senescent cells can contribute to the development of many diseases, including cancer, and are an essential factor in aging. However, they also play important roles in other biological processes, such as embryonic development, childbirth, wound healing, and tissue repair.
The number of times a cell can divide before reaching senescence is called its Hayflick limit, generally around 60 divisions.
We need a healthy amount of active NK cells to control aging and reduce age-related ill-health.
Allogenic Super NK Therapy
Super NK Cells Therapy:
Natural killer (NK) cells are a type of lymphocyte that plays a crucial role in removing senescent cells, which can accumulate with age and contribute to aging-related diseases.
What NK Cells Do:
NK cells are part of the innate immune system and are the primary innate lymphocytes that eliminate senescent cells. They also eliminate cells infected with viruses or other pathogens, as well as pre-malignant cells.
How NK Cells Kill Senescent Cells:
NK cells kill senescent cells by releasing perforin and granzymes, which create an opening in the target cell that allows the NK cell to insert the granzymes. NK cells also produce IFN-γ.
NK Cell Therapy:
NK cell-based therapies, such as adoptive NK cell therapy, are promising approaches to address the challenges of aging. One study found that NK cell infusion reduced senescent cells in vitro and immunosenescence in humans. Another study found that combining adoptive NK cell infusion with a dopamine-releasing peptide reduced senescent cells in aged mice.
Aging & Senescent Cells:
The classic hallmark of aging is the cumulation of the body's senescent cells (zombie cells). Senescent cells are cells that have aged and permanently stopped dividing but have not died. They can build up in tissues over time and release harmful substances that can damage healthy cells and cause inflammation.